☠️ Rune Catalyst: Poison
A catalyst rune that poisons targets on hit.
LAST UPDATED: APRIL 2026
Overview
A catalyst rune that poisons targets on hit.
This Rare rune item can be sold to any vendor for 600 gold.
When properly socketed, it unlocks effects not listed in any basic guide.
Item Statistics
How to Obtain
Obtained from the Runemaster, as dungeon rewards, or by disenchanting equipment of equal or higher rarity.
Lore
Legends say the first Rune Catalyst: Poison was forged during the Crimson Accords, a turbulent era when Vampires and Werewolves clashed under a blood moon. Handling the Rune Catalyst: Poison without gloves is a mistake made only once.
The rune pulses faintly, as if it remembers every enchantment ever inscribed upon it.
Tips
Socket the Rune Catalyst: Poison into equipment that already shares its primary stat for a multiplicative bonus. Disenchanting a duplicate rune of higher quality yields useful enchanting dust.